Influenza can lead to hospitalization, even death. Each year, on average 35,000 people die from flu in the U.S. The majority are over 65. Being healthy as an ox won't make you resistant to it. So the U.S. Centers for Disease Control and Prevention recommends getting vaccinated. Concerned about the vaccine's risk, safety, makeup and side effects? Flu virus strains change, but did you know the most infective strain hit in 1918-19? It killed 40 million people rivaling the Black Death of Europe in the 14th century!